Jill Valentine is one of the last people left in Raccoon City who could see with her own eyes the atrocities committed by Umbrella. To get rid of her, Umbrella reaches for its ultimate secret weapon – Nemesis!

The game also includes the addition of Resident Evil Resistance, a new 1 vs. 4 online multiplayer game in the Resident Evil universe in which four Survivors must face off against the sinister Operation Brain.